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2 edition of Analysis of genetic events in the development of hepatocellular carcinoma. found in the catalog.

Analysis of genetic events in the development of hepatocellular carcinoma.

John E. Prime

Analysis of genetic events in the development of hepatocellular carcinoma.

by John E. Prime

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  • 20 Currently reading

Published by Oxford Brookes University in Oxford .
Written in English


Edition Notes

Thesis (Ph.D.) - Oxford Brookes University, Oxford, 2000.

ContributionsOxford Brookes University. School of Biological and Molecular Sciences.
The Physical Object
Paginationxx, 305p. :
Number of Pages305
ID Numbers
Open LibraryOL18588066M

  Hepatocellular carcinoma (HCC) is the third cause of cancer mortality worldwide 1. Chronic liver infection due to hepatitis B or C virus (HBV or HCV) infection is Cited by: 2. Fig. 1: Selection of immune features by LASSO Cox analysis in hepatocellular carcinoma (HCC) patients with early stage. Fig. 2: Correlation of immune cell infiltration and clinical outcome. Fig. 3.

The combination of atezolizumab and bevacizumab showed encouraging antitumor activity and safety in a phase 1b trial involving patients with unresectable hepatocellular carcinoma. In a global. Treatment options for hepatocellular carcinoma depend on a number of factors: the number, size and location(s) of tumors present in the liver; the presence of metastatic cancer sites; the severity of liver disease; the functional status of the patient; and local resources/expertise.

Genetic alterations in specific driver genes lead to disruption of cellular pathways and are critical events in the instigation and progression of hepatocellular carcinoma (HCC). As a prerequisite for individualized cancer treatment, we sought to characterize the landscape of Cited by: Download Citation | Comprehensive genetic analysis of cholangiolocellular carcinoma with a co-existent hepatocellular carcinoma (HCC)-like area and metachronous HCC | Background: The genetic.


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Analysis of genetic events in the development of hepatocellular carcinoma by John E. Prime Download PDF EPUB FB2

The completely assembled human genome has made it possible for modern medicine to step into an era rich in genetic information and high-throughput genomic analysis. These novel and readily available genetic resources and analytical tools may be the key to unravel the molecular basis of hepatocellular carcinoma (HCC).Cited by: Analysis of genetic events in the development of hepatocellular carcinoma.

(Thesis) Prime JE. Publisher: Oxford Brookes University [] Metadata Source: The British Library Type: Thesis. Abstract. No abstract supplied. Menu. Formats. Abstract. EThOS. About. About Europe PMC Author: Prime Je.

Hepatocellular carcinoma (HCC) is one of the human cancers clearly linked to viral infections. Although the major viral and environmental risk factors for HCC development have been unravelled, the oncogenic pathways leading to malignant transformation of liver cells have long remained by: Genetic alterations in specific driver genes lead to disrup- tion of cellular pathways and are critical events in the instigation and progression of hepatocellular carcinoma.

Abstract. Hepatocellular carcinoma (HCC), a major type of liver cancer, is a clinically and biologically heterogeneous malignancy. Recent advances in next-generation sequencing (NGS), a massively parallel nucleotide sequencing technology, allow researchers for cost-effective and simultaneous identification of genetic alterations, transcriptomic changes at much greater sensitivity, Author: Xiyang Wei, Niya Liu, Xin Wei Wang, Junfang Ji.

hepatocellular carcinoma (HCC) has improved significantly in the last decade. Certainly, cumulative data from high-throughput analyses of large number of samples have provided an accurate landscape of HCC genetic alter-ations.

This has enabled us to delineate some of the key events that might dominate tumor development and Size: 3MB. Hepatocellular carcinoma is the sixth most common malignancy and the third most common cause of cancer deaths world wide.

The major risk factors include chronic viral infection (HBV and HCV), alcoholic/nonalcoholic liver disease, environmental carcinogens (i.e. aflatoxin B1 (AFB), and inherited genetic disorders (Wilson's disease, hemochromatosis, αantitrypsin deficiency, and Cited by: Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, accounting for >, new cases andmortalities per year.

Half of these new cases and mortalities were estimated to occur in China. The high rates of HCC in China are largely due to the prevalence of chronic hepatitis B virus (HBV) by: Genetic alterations in hepatocellular carcinoma may be targeted by therapies that are currently available or under development: Mutations of the TERT promotor, found in 44% of the cancers studied, may be targeted with telomerase inhibitors that are under development.

Hepatocellular carcinoma (HCC) is one of the most lethal cancers, and affects many of the world's populations. Various aetiologies have been linked to HCC development Cited by:   Understanding the intratumoral heterogeneity of hepatocellular carcinoma is instructive for developing personalized therapy and identifying molecular biomarkers.

Here we applied whole-exome sequencing to 69 samples from 11 patients to resolve the genetic architecture of subclonal diversification.

Spatial genomic diversity was found in all 11 hepatocellular carcinoma cases, with Cited by: Analysis of genetic events in the development of hepatocellular carcinoma. Author: Prime, John E. ISNI: Awarding Body: Oxford Brookes University Current Institution: Oxford Brookes University Date of Award: Availability of Full Text.

Hepatocellular carcinoma (HCC) is one of the major causes of cancer deaths worldwide. New diagnostic and therapeutic options are needed for more effective and early detection and treatment of this Cited by:   Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, and prior attempts to develop genomic-based classification for HCC have yielded highly divergent results, indicating difficulty in identifying unified molecular by: Introduction.

Hepatocellular carcinoma (HCC) is the second cause of cancer-related mortality mortality is rising and considering the dismal results of recent clinical trials testing systemic agents, it seems more difficult to treat than initially HCC is composed of a unique combination of somatic alterations including genetic, epigenetic, transcriptomic and Cited by: Hepatocellular carcinoma (HCC), a major type of liver cancer, is a clinically and biologically heterogeneous malignancy.

Recent advances in next-generation sequencing (NGS), a. Analysis of Genetic Damage and Gene Polymorphism in Hepatocellular Carcinoma (HCC) Patients in a South Indian Population Article in Digestive Diseases and Sciences 58(3). cancer mortality rate and has limited therapeutic op-tions.

We analyzed hepatocellular carcinoma (HCC) cases by whole-exome sequencing and DNA copy number analyses, and we analyzed HCC cases by DNA methylation, RNA, miRNA, and uencingandmutation analysis identified significantly mutated genes. Pan Q, Long X, Song L, Zhao D, Li X, Li D, et al.

Transcriptome sequencing identified hub genes for hepatocellular carcinoma by weighted-gene co-expression analysis. Oncotarget. ;–99 Author: Guiji Zhang, Xia Tang, Xia Tang, Li Liang, Wanfeng Zhang, Dewei Li, Xiaoyuan Li, Dachun Zhao, Yaqiu.

Fang W, Piao Z, Simon D, Sheu JC, Huang S () Mapping of a minimal deleted region in human hepatocellular carcinoma to 1p–p and mutational analysis of the RIZ (PRDM2) gene localized to the by:. Mendelian genetic predisposition to hepatocellular carcinoma.

The liver is a very rare target of classical cancer predisposition syndromes. The most frequent monogenic syndromes that predispose to breast, ovarian, or colorectal cancers are usually not associated with development of liver tumors.

1 Exceptionally, HCC can develop in patients with APC germ-line mutations. 2 However, HCC Cited by: Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide contributing to approximatelydeaths each year with this number on the rise in the developing world. The aetiology of HCC has been well characterised, including chronic hepatitis B and C infection as well as alcoholic cirrhosis.Liver cancer has the second highest worldwide cancer mortality rate and has limited therapeutic options.

We analyzed hepatocellular carcinoma (HCC) cases by whole-exome sequencing and DNA copy number analyses, and we analyzed HCC cases by DNA .